Abstract

Human health has a significant importance and it is directly affected by a number of factors like different diseases including microbial and viral infections. Up till now we have paid attention to the disease causing viruses and pathogens and less has been investigated about the usefulness of normal viral flora. One such orphan virus is Torque Teno Virus (TTV). The virus is present in healthy as well as diseased population, indicating its high prevalence. The virus is ubiquitous to human body as it is present in almost all tissues and organs and this is the property that can be utilized for targeted drug delivery. Another potentially useful property of this virus is TTV derived Apoptosis Inducing protein that can be a hope for the affectees.

Highlights

  • Viruses are small, tiny infectious agents that use the host cell machinery for replication

  • On the other hand there are certain other agents that are associated with hepatocytes but their clear association with hepatitis is not established yet and they are Hepatitis G Virus (HGV) and Torque Teno Virus (TTV) [3,4]

  • It is yet to be known that which type of cells provide replication machinery for TTV, some studies have shown the presence of mRNA forms and double stranded DNA of TTV in bone marrow, in various human organs and in tissues which indicates that they can be an active replication sites of TTV

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Summary

Introduction

Tiny infectious agents that use the host cell machinery for replication. The first ever virus to be identified and reported was Tobacco Mosaic Virus. The word “virus” is derived from Latin word meaning “poison”. It is believed by certain schools of thoughts that viruses have co-evolved with humans. Viruses are composed of two essential parts i.e. Viral Genome composed of DNA or RNA which could be either single stranded or double stranded and a protein coat which surrounds the genome and its symmetry can be either helical, icosahedral or complex, In some viruses the protein coat is embedded by a lipid bilayer derived from host cell making third part of their structure [1,2]

Hepatic Human Viruses and Historical Background of TTV
Discovery of Torque Teno Virus
Structure and Genomic Organization of Torque Teno Virus
Tumor Immunology Vaccines
Replication Mechanism of TTV
Phylogenetic Variation of TTV
Genotypes of TTV
Torque teno mini virus
Small anellovirus
Torque teno midi virus
Prevalence and Sociodemography of TTV
Modes of Transmission of TTV
TTV Immunology
TTV Pathogenicity
Cell Tropism
TTV as a Commensal Virus
Animal Torque Teno Virus
Resemblance of TTV with Chicken Anemia Virus
Resemblance of TTV with Hepatitis C Virus
Epstein Bar Virus as Helper Virus for TTV
Findings
TTV as a Potential Targeted Drug Delivery System
Full Text
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