Abstract

The role of antibody in rejection of transplanted organs was the subject of debate in the early days of transplantation. Peter Gorer was the first to describe the role of antibody and Peter Medwar championing cell-mediated immunity. Following the death of Gorer's in 1961, the concept of antibody-mediated rejection faded into the background. However, by 1997 demonstration of the relative sensitivity and specificity of C4d staining in peritubular capil‐ laries in identifying antibody mediated rejection raised the hope that a rigorous morphological classification could be devised.

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