Abstract
Current advances in the application of dynamic NMR studies of DNA/RNA intra–and inter molecular effect on ring inversion rate constants for molecular diagnosis of gum cancer
Highlights
The high incidence rate of gum cancer as well as its progressiveness has led researchers to continually examine and pursue better prevention, diagnosis, prognosis, and treatment techniques to decrease mortality rates and comorbidity from the disease
By implementing variations of the technique to study a wide range of samples such as commercially available cell lines, FFPP sections, and in vivo and ex vivo tissue, the potential of dynamic NMR studies of DNA/RNA intra–and inter molecular effect on ring inversion rate constants for molecular diagnosis of gum cancer as a viable option for a future diagnostic technology of gum cancer and other disease states has been shown
The engagement of the clinical community in supporting more comprehensive studies both in vivo and ex vivo, cognizant of all variables and considering a wide range of controls, gathered from a representative spectrum of the population would be vital to take the technique a step closer to gum cancer diagnosis. If such studies could be undertaken and the reliability of the technique proven, dynamic NMR studies of DNA/RNA intra– and inter molecular effect on ring inversion rate constants for molecular diagnosis of gum cancer could have a real future in clinical diagnostics of gum cancer and similar ontologies (Figure 1)
Summary
The high incidence rate of gum cancer as well as its progressiveness has led researchers to continually examine and pursue better prevention, diagnosis, prognosis, and treatment techniques to decrease mortality rates and comorbidity from the disease. Does dynamic NMR studies of DNA/RNA intra–and inter molecular effect on ring inversion rate constants for molecular diagnosis of gum cancer have the potential to identify cancerous and precancerous tissue, it has the ability to probe deeper into the disease fingerprint to elucidate its underlying mechanisms.
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