Abstract

Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Chitosan NPs being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. Chitosan is natural biopolymer which can be easily functionalized to obtain the desired targeted results and is also approved by GRAS (Generally Recognized as Safe by the United States Food and Drug Administration [US FDA]). Various methods for preparation of chitosan NPs include, ionic cross-linking, covalent cross-linking, reverse micellar method, precipitation and emulsion-droplet coalescence method. Chitosan NPs are found to have plethora of applications in drug delivery diagnosis and other biological applications. The key applications include ocular drug delivery, per-oral delivery, pulmonary drug delivery, nasal drug delivery, mucosal drug delivery, gene delivery, buccal drug delivery, vaccine delivery, vaginal drug delivery and cancer therapy. The present review describes the formation of chitosan, synthesis of chitosan NPs and their various applications in drug delivery.

Highlights

  • Nanoparticles (NPs) can be defined as submicron colloidal drug carrier systems which are composed of natural or artificial polymers ranging in size between 10 and 100 nm

  • The present review describes the formation of chitosan, synthesis of chitosan NPs and their various applications in drug delivery

  • Chitosan NPs are effective in drug delivery and enhance the therapeutic efficacy of the drugs

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Summary

Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting

Unnati Garg ID , Swati Chauhan ID , Upendra Nagaich ID , Neha Jain* ID Amity Institute of Pharmacy, Amity University, Sector-125, Noida, Uttar Pradesh-201303. Article info Article History: Received: 26 Sep. 2018 Revised: 11 Jan. 2019 Accepted: 13 Apr. 2019 epublished: 1 June 2019 Keywords: • Chitosan • Nanoparticles • Biodegradable • Applications • Drug delivery

Introduction
Improved DNA carrying capacity and solubility of chitosan
Hydrophobically modified glycol chitosan NPs
Findings
Conclusion
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