Abstract
8603 Background: Our TT studies demonstrate that long term progression free survival is achievable in MM pointing to the possible curability of MM. We report here on the base line characteristics of 33/231 TT1 patients and 109/475 TT2 patients qualifying for PFS-10, including 45/245 randomized to the control arm and 64/230 randomized to thalidomide. Methods: Baseline and response levels were compared between <10yr and >=10yr survivors and logistic regression applied to identify the critical features linked to PFS-10 status. Results: Compared to the remainder, PFS>=10yr and CCR>=10yr were characterized by lower frequencies of cytogenetic abnormalities (CA), B2M>=3.5mg/L and age >=65yr. More females and more patients with platelets >150.000/uL qualified for the >=10yr category. Finally, timely administration of 2 transplants was also over-represented in these patients. Conclusions: Long-term survival PFS-10 and CCR-10 were adversely affected by by CA and elevated B2M levels. Females more frequently attained PFS-10. Assessment of MRD by 8-color flow cytometry in these patients is in progress and will be presented at the meeting. Clinical trial information: NCT00580372, NCT 00083551. [Table: see text] [Table: see text]
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