Abstract
Electrophoretic deposition (EPD) was used to produce a multilayer coatings system based on chitosan/curcumin coatings on poly-ether-ether-ketone (PEEK)/bioactive glass (BG)/hexagonal boron nitride (h-BN) layers (previously deposited by EPD on 316L stainless steel) to yield bioactive and antibacterial coatings intended for orthopedic implants. Initially, PEEK/BG/h-BN coatings developed on 316L stainless steel (SS) substrates were analyzed for wear studies. Then, the EPD of chitosan/curcumin was optimized on 316L SS for suspension stability, thickness, and homogeneity of the coatings. Subsequently, the optimized EPD parameters were applied to produce chitosan/curcumin coatings on the PEEK/BG/h-BN layers. The multilayered coatings produced by EPD were characterized in terms of composition, microstructure, drug release kinetics, antibacterial activity, and in vitro bioactivity. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) confirmed the deposition of chitosan/curcumin on the multilayer coating system. The release of curcumin upon immersion of multilayer coatings in phosphate-buffered saline (PBS) was confirmed by ultraviolet/visible (UV/VIS) spectroscopic analysis. The antibacterial effect of chitosan/curcumin as the top coating was determined by turbidity tests (optical density measurements). Moreover, the multilayer coating system formed an apatite-like layer upon immersion in simulated body fluid (SBF), which is similar in composition to the hydroxyapatite component of bone, confirming the possibility of achieving close bonding between bone and the coating surface.
Highlights
Worldwide, millions of patients use implanted medical devices, including hip/knee joints, pacemakers, cardiovascular stents, dental implants, and so on
Since there are no previous studies discussing the mechanism of electrophoretic deposition (EPD) of chitosan/curcumin coatings, we investigated in this study the EPD of chitosan/curcumin mixtures under different conditions
The concept of multilayer coatings composed of PEEK and chitosan-based coatings obtained by EPD has been introduced recently [28]; the use of curcumin in the chitosan layer has been investigated for the first time in this study
Summary
Millions of patients use implanted medical devices, including hip/knee joints, pacemakers, cardiovascular stents, dental implants, and so on. For improvement of metal implant bioactivity, surface modification approaches are being put forward, which involve, for example, coating the implants with inorganic materials like bioactive glass, hydroxyapatite, and calcium-phosphate cements [6,7]. These bioceramic coatings facilitate biocompatibility, osteo-conductivity, osteo-inductivity, and may impart antimicrobial activity [8]. The combination of PEEK and h-BN may lead to a coating with improved mechanical properties, while the addition of bioactive glass particles should enhance the bioactivity of the coatings, facilitating the bone-bonding ability and rendering the coatings of interest for orthopedic applications. The concept of multilayer coatings composed of PEEK and chitosan-based coatings obtained by EPD has been introduced recently [28]; the use of curcumin in the chitosan layer has been investigated for the first time in this study
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
