Abstract
Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant‐derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin‐mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μm curcumin, followed by Annexin V/propidium iodide double‐staining assay to evaluate cell apoptosis. Western blot analysis was used to analyze caspase‐3 expression in response to curcumin treatment. Gastrin levels in culture medium were also monitored. Mice bearing gastric cancers were treated with curcumin, followed by analysis of tumor caspase‐3 expression, gastric acid pH, and gastric secretion in serum. Curcumin prominently inhibited gastric cancer cell proliferation and promoted cell apoptosis. Caspase‐3 was upregulated by curcumin treatment. Curcumin also reduced gastrin secretion. Curcumin dramatically inhibited tumor growth, increased gastric pH, and reduced gastric secretion. In gastric cancer, curcumin suppresses gastrin‐mediated acid secretion, which inhibits gastric cancer progression.
Highlights
Hyperacidity in the stomach is known to promote the progression of gastric cancer
It was found that the dose of curcumin at 25 lM was the lowest dose to suppress the growth of gastric cancer cell line to the most extent (Fig. S1)
To further confirm the antitumor effects of curcumin, we incubated gastric cancer cells with 25 lM curcumin followed by evaluation of cell proliferation and apoptosis
Summary
Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant-derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin-mediated acid secretion in suppressing gastric cancer. Mice bearing gastric cancers were treated with curcumin, followed by analysis of tumor caspase-3 expression, gastric acid pH, and gastric secretion in serum. Curcumin suppresses gastrin-mediated acid secretion, which inhibits gastric cancer progression. Gastric acid secretion is stimulated by gastrin [10] This is supported by the increased serum gastrin levels in high-level gastric cancer patients. This gave birth to a number of strategies to prevent cancer cell progression by reducing gastrin expression [11]. Curcumin inhibits gastric cancer progression curcumin correlates to its regulation of gastric pH via gastrin secretion
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