Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway.

Xiaolu Zhang,Jingjing Zhao,Shouzhu Xu,Xiaoming Pang,Juntian Liu

doi:10.1155/2020/3245653

Abstract

Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.

Highlights

Ischemic cardiocerebrovascular disease is a common disease that seriously deteriorates human health
We explored whether curcumin can diminish aldosterone-induced C-reactive protein (CRP) generation in vascular smooth muscle cells (VSMCs)
We examined whether the reactive oxygen species (ROS)-ERK1/2 signaling pathway mediates the anti-inflammatory and cardiovascular protective effects of curcumin

Summary

Introduction

Ischemic cardiocerebrovascular disease is a common disease that seriously deteriorates human health. We explored whether curcumin can diminish aldosterone-induced CRP generation in VSMCs. We examined whether the ROS-ERK1/2 signaling pathway mediates the anti-inflammatory and cardiovascular protective effects of curcumin. E results revealed that incubation of the cells with curcumin at 1–100 μmol/L for 24 h did not affect the viability of VSMCs (Figure 1).

Results

Conclusion