CURCUMIN'S IMPACT ON CARBAMAZEPINE PHARMACOKINETICS AT VARIOUS DOSES IN RABBITS

Abstract

The purpose of this study is to explore the influence of preadministration of Curcumin (CUR), at two distinct dosages (60 and 90 mg/kg body weight per day, 8 days, p.o), on the pharmacokinetic (PK) profile of Carbamazepine (CBZ) in rabbits. Eighteen rabbits were divided randomly into 3 groups (6 rabbits per group). Control group were given (20 mg/kg of CBZ, as single dose, p.o.). The first and second test groups were given CUR (60 and 90 mg/kg body weight per day, 8 days, p.o). On the eighth day, CBZ (20 mg/kg) was administered one hour after giving CUR’s last dose. Blood was drawn from a marginal ear vein at various intervals (0.5, 1, 1.5, 2, 2.5, 3.5, 4, 6, 12, and 24 hr). CBZ levels in serum were determined using a Chemiluminescent Enzyme Immunoassay (CLEIA). Cmax, tmax, AUC0–24, AUC0–∞, Ke and CL/F were calculated. Statistically insignificant differences were found in the different PK parameters of CBZ. The results demonstrated that prior treatment of CUR at both concentrations, had no influence on PK parameters of CBZ in rabbits.