Abstract
Colitis is associated with dysmotility and reduced responsiveness of the colon to contractile agonists. Recent reports have shown that curcumin, the active constituent of Curcuma longa, was effective against experimentally induced colitis in rodents. These studies showed that curcumin prevented mucosal damage and diarrhea. The main objective of this study was to investigate the effect of curcumin on carbachol‐induced contraction of colon segments from rats with TNBS‐induced colitis. MPO activity in colon segments from TNBS‐treated rats (17.65 ± 5.43 units/min/mg tissue) was greater than in segments from control rats (0.40 ± 0.33 units/min/mg tissue). The maximum response was significantly reduced in colitic (27.2 ± 5.8 mg/mg tissue weight) compared to non‐colitic (58.0 ± 3.9 mg/mg tissue weight) rats. Carbachol produced concentration‐dependent contraction of colon segments from TNBS‐treated rats with or without treatment with curcumin. There was no significant difference in the potency of carbachol in colon segments from TNBS‐treated rats with or without curcumin treatment. In addition, there was no significant deference in the maximum response to carbachol between control rats (58.0 ± 3.9 mg/mg tissue weight, n=4) and TNBS‐rats (63.1 ± 6.6 mg/mg tissue weight, n=4) treated with curcumin indicating reversal of impaired contractility.
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