Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials.

Mohammad Alizadeh,Sorayya Kheirouri

doi:10.1051/bmdcn/2019090423

Mohammad Alizadeh, Sorayya Kheirouri

Open Access

https://doi.org/10.1051/bmdcn/2019090423

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Journal: BioMedicine	Publication Date: Nov 14, 2019
Citations: 47	License type: CC BY 4.0

Affiliation: Tabriz University of Medical Sciences

Abstract

Objective: This systematic review and meta-analysis was conducted to collate the effects of curcumin on MDA and antioxidant markers in individuals with diseased conditions. In this study the research question was “does curcumin supplementation improves oxidative stress and antioxidant defense enzymes in human subjects compared to a group without curcumin supplementation?Methods: This research included randomized controlled trials published in English in any year, in which intervention with curcumin was compared to either placebo, or standard of care or no intervention. Pubmed, Embase, Cochrane Central, Scopus and Google Scholar were searched. Meta-analysis was performed using RevMan (version 5.3), with standardized mean differences (SMD) and random-effects models.Results: One hundred twenty-seven titles and abstracts were identified which 17 articles were included for final analysis. The number of participants ranged from 22 to 160 across the included studies. The duration of intervention, dose of curcumin and location of outcomes measurements varied across the studies. Curcumin significantly reduced MDA [SMD −0.46 (95% CI: −0.68 to −0.25)] and increased superoxide dismutase (SOD) [0.82 (0.27 to 1.38)], catalase [10.26 (0.92 to 19.61)], and glutathione peroxidase [8.90 (6.62 to 11.19)] when compared with control group. Subgroup analyses displayed that curcumin could significantly reduce MDA levels with or without use of piperine, however it could increase SOD level in presence of piperine.Conclusions: These findings suggest that curcumin may be used as an adjunct therapy in individuals with oxidative stress. The administration of piperine with curcumin may enhance the efficacy of curcumin on antioxidant defense system.

Highlights

Oxidative stress is a condition in which reactive oxygen species (ROS) are produced in the cells of living beings
An increase in the concentration of oxidants compared to antioxidants is termed as oxidative stress, which can impair proteins, lipids, DNA and other components of Abbreviations: antioxidant response element (ARE), Antioxidant response element; CAT, Catalase; Comprehensive Meta-Analysis (CMA), Comprehensive Meta- Analysis; FOXO, Forkhead box O; GC-MS, Gas chromatography mass spectrometry; GSH, Glutathione; GPX, Glutathione peroxidase; GR, Glutathione reductase; HO-1, Hemeoxygenase-1; Keap1, Kelch ECH associating protein 1; MDA, Malondialdehyde; inducible nitric oxide synthase (iNOS), Nitric oxide synthase; nitrous oxide (NO), Nitrous oxide; nuclear factor erythroid 2-related factor 2 (Nrf2), Nuclear factor erythroid 2-related factor 2; NF-ĸB, Nuclear factor-kappaB; proliferator-activated receptor gamma coactivator 1-a (PGC-1a), Peroxisome proliferatoractivated receptor gamma coactivator 1-a; randomized controlled trial (RCT), Randomized controlled trial; ROS, Reactive oxygen species; GSH, Reduced glutathione; SIRT, Sirtuin; SOD, Superoxide dismutase; TCF/LEF, T cell factor/lymphoid enhancer factor; thiobarbituric acid reactive substances (TBARS), Thiobarbituric acid-reactive substances; TAC, Total antioxidant capacity. * Corresponding author
Some articles were excluded for certain outcomes as follows: Judaki et al [18] study for glutathione peroxidase (GPx); Pakfetrat et al [19] study for GPx, CAT and GR; Panahi et al [20] study for TAC; Sudheeran et al [21] study for SOD, CAT and GSH outcomes since the data had been presented as g or mg protein

Summary

Introduction

Oxidative stress is a condition in which reactive oxygen species (ROS) are produced in the cells of living beings. The concentration of ROS is regulated by internal defense mechanisms including enzymatic and non-enzymatic antioxidants. An increase in the concentration of oxidants compared to antioxidants is termed as oxidative stress, which can impair proteins, lipids, DNA and other components of Population. Defined as placebo intervention or standard therapy Outcome. MDA and antioxidant defense enzymes (SOD, CAT, TAC, GSH, GPx, and GR) Setting. Superoxide dismutase (SOD); Total antioxidant capacity (TAC); Malondialdehyde (MDA); Reduced glutathione (GSH); Catalase (CAT); Glutathione reductase (GR); Glutathione peroxidase (GPX); Glutathione (GSH)

Methods

Results

Discussion

Conclusion