Abstract
Curcumin is one of the polyphenols, which has been known for its medicinal use since long time. Curcumin shows poor solubility and low absorption, and therefore, its use as nanoparticles is beneficial due to their greater solubility and absorption. The main aim of the present study was the formation of curcumin nanoparticles (Nano curcu), evaluation of their antibacterial activity against human pathogenic bacteria and formulation of Nano curcu-based cream. We synthesized Nano curcu by sonication method. The synthesis of Nano curcu was assessed for their solubility in water and by UV–visible spectrophotometry. Further, the nanoparticles were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, nanoparticle tracking and analysis, and zeta potential analysis. In vitro antibacterial activity of Nano curcu was evaluated against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The cream containing Nano curcu was found to be effective against human bacterial pathogens and hence can be used for treatment of bacterial diseases.
Highlights
Curcuma longa L. is a perennial herb, which belongs to family Zingiberaceae, and commonly known as turmeric
We report physico-chemical synthesis of Nano curcu, their formulation and activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa
Nano curcu detection was done by UV–visible spectroscopy and it was scanned in the range of 200–800 nm
Summary
Curcuma longa L. is a perennial herb, which belongs to family Zingiberaceae, and commonly known as turmeric. Curcumin is found to be effective against 20 types of Candida species (Martins et al 2009) It has been observed by trials on human and mouse that oral consumption of curcumin shows less bioavailability and it undergoes intestinal metabolism (Sharma et al 2005; Anand et al 2007). These obstacles of curcumin can be eliminated by synthesis of curcumin nanoparticles (Nano curcu), liposomes, micelles, and phospholipid complexes which can be used for the purpose of longer circulation, permeability and increased resistance to metabolic processes (Aggarwal et al 2006; Nawaz et al 2011; Ravichandran 2013). PLGA-loaded Nano curcu are one of the efficient tools
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
