Abstract
The present study is aimed at formulating Genipin crossed curcumin loaded sericin NPs (Cur-SNPs) for the biomedical application in terms of anti-inflammatory and antioxidant potential. Cur-SNPs were prepared by employing modified desolvation method and crosslinking using genipin (Gn) and optimization for particle size, drug entrapment and loading. The optimized curcumin loaded sericin NPs (Opt-Cur-SNPs) exhibited particle size (263±3.5 nm), entrapment efficiency (85.7 ± 1.20%), drug loading (47.0 ± 1.23%) and zeta potential (-25.65 mV). The in-vitro drug release data revealed that 72.0 ± 2.3% and 83.1 ± 1.0% curcumin release over a span of 60 h in simulated gastric fluid and colonic pH. In-vivo antioxidant activity and anti-inflammatory activity showed significant results (p<0.05 and p<0.01) in comparison to control rats. The pharmacokinetic study revealed that the formulation holds better bioavailability and sustained release as compared to parent API. The present study confirms the hypothesis, that the Cur-SNPs can be used for biomedical application.
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