Abstract
Parkinson’s disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating curcumin is beneficial to improving its aqueous solubility and bioavailability. The curcumin-loaded HSA nanoparticles were acquired in the particle size and at the zeta potential of 200 nm and −10 mV, respectively. The curcumin-loaded human serum albumin nanoparticles ameliorated Parkinson’s disease features in the C. elegans model, including body movement, basal slowing response, and the degeneration of dopaminergic neurons. These results suggest that curcumin nanoparticles have potential as a medicinal nanomaterial for preventing the progression of Parkinson’s disease.
Highlights
Serum Albumin NanoparticlesParkinson’s disease (PD) is one of the most frequently diagnosed age-related diseases next to Alzheimer’s disease
This study focused on the utilization of curcumin- (CU) loaded nanoparticles as a promising PD therapeutic agent
The preparation of the human serum albumin (HSA) nanoparticles can be achieved through the desolvation method, in which the desolving agents such as alcohol are added dropwise followed by the addition of a crosslinking agent, glutaraldehyde
Summary
Parkinson’s disease (PD) is one of the most frequently diagnosed age-related diseases next to Alzheimer’s disease. The prevalence of PD increases as age progresses, and patients are expected to have a decreased life expectancy [1]. Is diminished and when ~60% of the dopaminergic neurons of the substantia nigra par compacta have been lost [3]. Despite extensive research on PD, there is still no concrete mechanistic explanation as to how neurodegeneration starts. This restricted knowledge is the main hindrance in providing proper neuroprotective therapeutic advancement for PD. DZC nanocomplexes were used to inhibit dopaminergic neuron degeneration in C. elegans successfully, with no specific toxicity being induced
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