Abstract
Curcumin, one of the curcuminoid constituents which derived from Curcuma longa, has been extensively used as a pharmacological agent. This study was started with extraction of the curcuminoid from Curcuma longa where extraction was carried out with two different solvents (dichloromethane and ethanol), followed by isolation of curcumin from the other two components of curcuminoid. The pure curcumin was converted to its isoxazole derivative with the addition of NH2OH·HCl. The reaction product was characterized using mass spectrometry, UV/Vis and FTIR spectrophotometry. Optimization of the extraction and synthesis shows that for the extraction ethanol was a better solvent than dichloromethane with 12.67 % yield. Temperature and optimization time for synthesis of curcumin isoxazole were 70 °C and 8 hours, respectively.
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