Abstract
We intended to study the mechanism of the inhibitory action of curcumin on human non-small cell lung cancer A549 cell. The cell growth was determined by CCK-8 assay, and the results indicated that curcumin inhibited the cell proliferation in a concentration dependent manner. And to further confirm the relative anti-cancer mechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax, Bcl-2. We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells. In addition, curcumin affect the mitochondrial apoptosis pathway. These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway.
Highlights
Lung cancer has the highest incidence and mortality rate of all malignancies
We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells
Curcumin affect the mitochondrial apoptosis pathway. These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway
Summary
Lung cancer has the highest incidence and mortality rate of all malignancies. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers, the majority of which are at an advanced stage and unresectable when diagnosed (Parkin et al, 2005). Surgery is the most common treatment given with curative intent. Other treatments including radiotherapy, combined chemoradiotherapy and adjuvant chemotherapy are commonly used as well (NCCC, 2011). The side effects of the radiotherapy or chemotherapy promote much work on the new effective medicine in treating NSCLC. Traditional Chinese Medicine (TCM) is widely used for cancer treatment in China. Many support its use in treatment for cancer, yet scientific evidence for the effect of TCM needs to be established
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