Curcumin: Compound in Turmeric that Has the Potential to Increase Serum Interleukin-10 (IL-10) Levels After High-Intensity Exercise

Abstract

This study aims to analyze the effect of curcumin on serum IL-10 levels after high-intensity exercise. This experimental research uses pre and post-control group design. Research subjects were selected using purposive sampling technique. Next, the subjects were divided into 2 groups, namely group (K1) given placebo and group (K2) given curcumin. A total of 20 healthy men participated in this study who were selected based on inclusion and exclusion criteria. On the first day, all subjects collected data on the characteristics of the research subjects, then warmed up, then the subjects did exercises in the form of squad exercises and leg presses with an intensity of 80-90% of their maximum ability. Exercises are done in 4 sets, 10 repetitions for each form of exercise and rest between sets for approximately 60 seconds. On the second day, after 24 hours, all subjects had pre-test blood samples taken to measure serum IL-10 levels and were given intervention according to group. On the third day, after 24 hours, all subjects had post-test blood samples taken to measure serum IL-10 levels. Blood samples were analyzed in the laboratory using the ELISA method with the Human IL-10 ELISA kit catalog number MDBEH6154. The results of this study reported that the group given curcumin at a dose of 400 mg had significantly increased serum IL-10 levels (p<0.05). Increasing serum IL-10 levels, which is an anti-inflammatory cytokine, has the potential to control uncontrolled inflammation after exercise. So in this case, the anti-inflammatory properties of curcumin also have the potential to reduce post-exercise muscle pain. Reducing the intensity of pain after high intensity exercise is necessary to support body function. Keywords: Curcumin, Inflammation, Cytokines, Pain Intensity, Exercise