Curcumin: Analysis and Stability

Wafaa Zaghary,Marwa Zanoun,Tamer Sakr,Emily Hanna,Nermeen Abdallah

doi:10.21608/aprh.2019.6191.1069

Wafaa Zaghary, Marwa Zanoun + Show 3 more

Open Access

https://doi.org/10.21608/aprh.2019.6191.1069

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Abstract

Curcumin is a polyphenol extracted from Curcuma longa, used as a spice, in food coloring, and as a traditional herbal medicine. It has wide therapeutic platform as anti-oxidant, anticancer, anti-inflammatory and anti-infection properties. This review discusses the analytical methods used in determination of curcumin in various matrices with degradation profile, expected degradation products and stability tests.

Highlights

The first article referring to the use of Curcumin in human diseases was published in 19374.Curcumin possesses many pharmacological activities including antioxidant, anti–infection, anti–inflammation, anti
Curcumin is a special spice which is the functional ingredient in curry powder19, and a potential natural food coloring20; it impairs an attractive yellowish-orange color to food, authorized as a food additive by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1974, it's E number is E 10021
It is widely used in food applications including dairy products, fat emulsions, confectionery, soups and sauces22–31

Summary

INTRODUCTION

Methoxyphenyl)hepta-1,6-diene-3,5-dionealso known as diferuloylmethane Figure 1, is a phenolic compound present in many kinds of medicinal plants, especially in Curcuma longa (turmeric), and was first discovered and isolated in 1815 by Harvard College laboratory scientists Vogel and Pelletier. Curcumin is a special spice which is the functional ingredient in curry powder, and a potential natural food coloring; it impairs an attractive yellowish-orange color to food, authorized as a food additive by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1974, it's E number is E 10021. It is widely used in food applications including dairy products, fat emulsions, confectionery, soups and sauces. Pharmaceutical dosage Acetonitrile and water (50:50 v/v) UV at 425 nm forms acidified with 2% acetic acid. Pharmaceutical dosage Ethanol, water and acetonitrile (80:10:10, Fluorescence forms v/v/v) detector: Excitation at 365 nm &. UV at 270 and 380 RP-C18 column nm Acetonitrile-methanol-trifluoroacetic acid-water (17.6:35.3:0.1:47.0, v/v/v/v)

99 Agilent Zorbax Eclipse

Findings

Oxidation of curcumin