Curcumin affects tracheal responsiveness and lung pathology in asthmatic rats.

Abstract

Curcumin has shown various pharmacological effects such as anti-inflammatory activities. In this study, the effects of curcumin on tracheal responsiveness and lung pathological features were evaluated in a rat model of asthma. Tracheal responsiveness and lung pathological features were evaluated in control rats (C), ovalbumin (OVA)-sensitized rats (as an animal model of asthma; A), A rats treated with curcumin (Cu, 0.15, 0.30, and 0.60mg/ml) and dexamethasone (D, 1.25μg/ml), (n=8 in curcumin-treated groups and n=6 in other groups). Curcumin and dexamethasone were added to animals' drinking water during the sensitization period. Asthmatic group showed increased lung pathological score and tracheal responsiveness to methacholine and OVA compared to control group (p<0.01 to p<0.001). Pathological features including interstitial inflammation, interstitial fibrosis, bleeding, and emphysema as well as tracheal responsiveness to methacholine and OVA, were significantly decreased in treated groups with dexamethasone and all concentrations of curcumin compared to group A (p<0.05 to p<0.001). Epithelial damage was also significantly decreased in treated groups with the two higher concentrations of curcumin (p<0.05 to p<0.001). Curcumin showed preventive effects on tracheal responsiveness and lung pathological features in asthmatic rats.