Curcumin: A Review of its’ Efficacy in the Management of Psoriasis

Abstract

Background:Psoriasis is a long-term chronic inflammatory, autoimmune and reoccur-ring skin condition. About 2% to 5% of the world's population is impacted by psoriasis. People af-fected by psoriasis are more prone to develop other health conditions including psoriatic arthritis, anxiety, depression and cardiovascular disorders. Long-term use of several synthetic medications used for their management has been showing typical severe side effects. Curcumin, a natural com-pound generated from the golden spice (Curcuma longa), has been recommended as a potential al-ternative for the management of psoriasis. Curcumin works at molecular level by binding with the various inflammatory receptors that play a key role in the initiation of psoriasis.Objective:The aim of this review is to report the use and discuss the mechanism of action of cur-cumin in the management of psoriasis and mutually overcome the side effects shown by the synthet-ic medications.Methods:For qualitative literature review PubMed, Scopus, Web of Science, Google Scholar, Google Books, and Science Direct meet the inclusion criteria.Results:Through ample literature surveys, curcumin has been proposed as a safe and therapeutic option for psoriasis as compared to synthetic medications.Conclusion:As traditional herb curcumin appears as a beneficiary medicament because of its anti-oxidant, anti-inflammatory and immune-modulating activities proposing minimal side effects. Thereby ensuring its defensive mechanism against psoriasis.