Abstract
BackgroundIn India, Curcumin (CMN) is popularly known as "Haldi", and has been well studied due to its economic importance. Traditional Indian medicine claims the use of its powder against biliary disorders, anorexia, coryza, cough, diabetic wounds, hepatic disorder, rheumatism and sinusitis. This study was designed to examine the possible beneficial effect of CMN in preventing the acute renal failure and related oxidative stress caused by chronic administration of cyclosporine (CsA) in rats. CMN was administered concurrently with CsA (20 mg/kg/day s.c) for 21 days. Oxidative stress in kidney tissue homogenates was estimated using thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) content, superoxide dismutase (SOD), and Catalase (CAT). Nitrite levels were estimated in serum and tissue homogenates.ResultsCsA administration for 21 days produced elevated levels of TBARS and marked depletion of renal endogenous antioxidant enzymes and deteriorated the renal function as assessed by increased serum creatinine, Blood Urea Nitrogen (BUN) and decreased creatinine and urea clearance as compared to vehicle treated rats. CMN markedly reduced elevated levels of TBARS, significantly attenuated renal dysfunction increased the levels of antioxidant enzymes in CsA treated rats and normalized the altered renal morphology.ConclusionIn conclusion our study showed that CMN through its antioxidant activity effectively salvaged CsA nephrotoxicity.
Highlights
In India, Curcumin (CMN) is popularly known as "Haldi", and has been well studied due to its economic importance
In conclusion our study showed that CMN through its antioxidant activity effectively salvaged CsA nephrotoxicity
Cyclosporine (CsA), a hydrophobic cyclic undecapeptide produced by the fungus Tolypocladium inflatum, can be considered the prototype of immunosuppressant that has revolutionized the management of allotransplantation
Summary
In India, Curcumin (CMN) is popularly known as "Haldi", and has been well studied due to its economic importance. This study was designed to examine the possible beneficial effect of CMN in preventing the acute renal failure and related oxidative stress caused by chronic administration of cyclosporine (CsA) in rats. Nitrite levels were estimated in serum and tissue homogenates. Cyclosporine (CsA) (formerly called cyclosporine A), a hydrophobic cyclic undecapeptide produced by the fungus Tolypocladium inflatum, can be considered the prototype of immunosuppressant that has revolutionized the management of allotransplantation. This drug and reversibly inhibits immunocompetent T-helper lymphocytes by suppressing the interleukin-2 driven proliferation of activated T-cells [1]. The functional changes caused by CsA are dose dependant and are usually reversible after short-term CsA treatment [4].
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