Abstract
Curcumin is a principal active ingredient of turmeric, extracted from the Curcuma longa plant. The presence of several curcuminoids (e.g., curcumin, demethoxycurcumin, bisdemethoxycurcumin, and cyclocurcumin) with extended π–π conjugation makes the Indian spice turmeric a bright yellow color. Curcumin can modulate various cellular targets and exhibits preventive and clinical efficacy against a wide variety of diseases such as inflammatory, proliferative, and angiogenic diseases, Alzheimer’s disease, malaria, cancer, HIV, etc. Curcumin has been widely exploited by several branches of research scientists to study the chemistry behind its biological and chemical significance. However, application of curcumin is limited as medicine due to its poor aqueous solubility and bioavailability. While there are recent reports on curcumin on solubility/bioavailability improvement using excipients/additives, there has been little discussion from the viewpoint of crystal engineering. There is a need for understanding of ...
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