Abstract
Dimethoate (technical and formulated) sublethal doses (1/20 of LD50) were ingested into male albino rats. The intoxicated rats were treated with cow and camel milk as an antitoxic diet to reduce the harmful of the pesticide (both forms). Energy compounds (ATP, ADP and AMP) as well as myokinase activity and also the respiratory system included cytochrome-c, Cytochrome-c-oxidase and succinate-cytochrome-c-reductase were studied in brain, liver and kidneys tissues of adult male albino rats during the experimental period of 3 months. LD50 of the technical and formulated dimethoate as well as the composition of cow and camel milks, were determined. ATP content of the three organs tissue was elevated, but the contents of ADP and AMP were reduced either by technical and formulated dimethoate effects relative to those of the normal healthy control. On the other hands, the effects of technical and formulated dimethoate on mitochondrial cytochrome-c contents and activity of Cytochrome-c-oxidase and succinate-cytochrome-c-reductase was studied. Cytochrome-c contents showed considerable decreases, but the activities of both enzymes of the mitochondrial respiratory system (cytochrome-c contents and Cytochrome-c-oxidase) were stimulated in liver, kidneys and brain tissues. In general, the formulated dimethoate ingestions were more toxic than the technical pesticide ingestions relative to those of normal healthy control. The treatment with Cow and camel milk as antioxidant agents observed antagonistic influence against the harmful of the present pesticide. The milk treatments attenuated the dimethoate toxicity and improved the organophosphorus pesticide disturbance in the present studied parameter. For energy system (ATP, ADP and AMP and also myokinase activity) as well as the respiratory system of cytochrome-c (cytochrome-c level, with cytochrome-c-oxidase and cytochrome-c-reductase activities) were about normalized nearly around of those values in brain, liver and kidneys tissues of the normal control. The desirable treatments of camel milk were more than those of cow milk treatments against the harmful of the technical and formulated dimethoate. In conclusion, the present investigation found that camel milk possesses a potential antitoxic effect and higher than those obtained by cow milk, these may be due to the presence of many beneficial agents. The therapeutic efficacy of camel milk has rather explained by lack of coagulation in an acidic condition of the animal stomach
Highlights
The pesticides are used to control and eradicate disease reactors, which in turn improve the agricultural production either in the fields or in the storehouse
Dimethoate belongs to the organophosphorus class of insecticides, which is activated to the corresponding oxygen analog, which in turn is responsible for its mammalian toxicity through acetylcholinesterase (AChE) inhibition
Cow milk samples were collected from the herds of Faculty of Agriculture, Cairo University, Giza, Egypt, whereas, camel milk samples were collected from areas around Research Institute of Animal Production, Dokki, Giza, Egypt
Summary
Dimethoate (technical and formulated) sublethal doses (1/20 of LD50) were ingested into male albino rats. Energy compounds (ATP, ADP and AMP) as well as myokinase activity and the respiratory system included cytochrome-c, Cytochrome-coxidase and succinate-cytochrome-c-reductase were studied in brain, liver and kidneys tissues of adult male albino rats during the experimental period of 3 months. ATP content of the three organs tissue was elevated, but the contents of ADP and AMP were reduced either by technical and formulated dimethoate effects relative to those of the normal healthy control. The treatment with Cow and camel milk as antioxidant agents observed antagonistic influence against the harmful of the present pesticide. For energy system (ATP, ADP and AMP and myokinase activity) as well as the respiratory system of cytochrome-c (cytochrome-c level, with cytochrome-c-oxidase and cytochrome-c-reductase activities) were about normalized nearly around of those values in brain, liver and kidneys tissues of the normal control.
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