Curative effect of stereotactic radiotherapy combined with TACE for patients with hepatic metastases of colorectal cancer and influence on the expressions of omentin-1 and Ang-2

Abstract

Objective To explore the curative effect of stereotactic radiotherapy combined with transcatheter arterial chemoembolization (TACE) for patients with hepatic metastases of colorectal cancer and influence on the expressions of omentin-1 and angiopoietin-2 (Ang-2). Methods A total of 90 patients with hepatic metastases of colorectal cancer from December 2013 to December 2015 in our hospital were selected as the research objects. Patients were divided into observation group and control group according to random number table method with 45 cases respectively. Patients in control group were treated with TACE, and patients in observation group were treated with stereotactic radiotherapy combined with TACE. After treatment, the clinical efficacy, expression levels of plasma omentin-1 and Ang-2, score of quality of life and adverse reaction were compared in the two groups. Results The objective response rate in observation group (82.2%) was significantly higher than that in control group (60.0%), and the difference was statistically significant (χ2=5.409, P=0.020). After treatment, the omentin-1 and Ang-2 expression levels in observation group were lower than those in control group [(43.7±18.1) ng/ml vs. (52.1±17.9) ng/ml, t=2.214, P=0.029; (2.0±0.2) g/L vs. (2.3±0.3) g/L, t=6.028, P<0.001]. The score of quality of life in observation group was significantly higher than that in control group [(87.6±11.2) vs. (68.7±10.3)], and the diffe-rence was statistically significant (t=8.332, P<0.001). There were no differences on the adverse reaction rates such as abnormal liver function (35.6% vs. 42.2%, χ2=0.421, P=0.517), nausea and vomiting (44.4% vs. 37.8%, χ2=0.413, P=0.520), skin injury (6.7% vs. 0, χ2=3.101, P=0.078) and fever (35.6% vs. 31.1%, χ2=0.202, P=0.655) between the two groups. Conclusion The implementation of stereotactic radiotherapy combined with TACE in the treatment of hepatic metastases of colorectal cancer is a safety and effective method. It can significantly reduce the expression levels of plasma omentin-1 and Ang-2, inhibit of tumor angiogenesis, and improve the quality of life of patients. Key words: Colorectal neoplasms; Radiosurgery; Transcatheter arterial chemoembolization; Angiopoietin-2; Omentin-1