Abstract
Tamoxifen is the commonly used adjuvant therapy for all stages of breast carcinoma. However, several studies have suggested an association between the use of tamoxifen in breast cancer patients and the subsequent development of endometrial carcinoma. Riboflavin, niacin and ascorbic acid are proved to be potent antioxidants and protective agents against many diseases including cancer. The objective of this article is to determine the curative effect of riboflavin, niacin and ascorbic acid on tamoxifen mediated endometrial carcinoma bearing rats in terms of lipid peroxidation and antioxidant status. In endometrial carcinoma bearing rats, levels of lipid peroxides were increased and the activities of enzymic and non-enzymic antioxidants were decreased. Oral administration of drug for 28 days restored lipid peroxide level and the activities of enzymic and non-enzymic antioxidants to near normal levels.
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