Abstract
Objective To study the curative effect of mitral valve replacement on rheumatic heart disease (RHD) and to analyze the dynamic changes of brain natriuretic peptide (BNP) level. Methods Forty-eight patients with RHD from August 2013 to July 2014 were included in the study. All of them underwent mitral valve replacement under low temperature and cardiopulmonary bypass. Through three dimensional ultrasound imaging, the changes of right ventricular function indexes [right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV), right ventricular ejection fraction (RVEF)] before and after operation were compared. The dynamic changes and clinical significance of BNP were observed and analyzed. Results Six months after operation, the levels of RVEDV [(34.2±12.7) ml ]and RVESV [(13.1±8.9) ml ]were significantly lower than before operation [(41.3±17.4) ml, (18.5±13.2) ml], while the levels of RVEF [(60.7±12.6)%] was significantly higher than before operation [(52.6±11.3)%] (P<0.05). Two days after operation, the concentration of plasma BNP [(1826.5±313.5) pg/ml] was significantly higher than that at postoperative 12 h and 1 week. Two days after operation, BNP began to decrease. One week after surgery, the final detection showed that the levels of BNP [(1135.7±276.4) pg/ml] was significantly lower than that at postoperative 12 h and 3 d. Conclusions Mitral valve replacement can well improve right ventricular function in patients with RHD without significant complication, which can be taken as a safe and effective therapy for clinical treatment of RHD. The concentration of BNP value is negatively correlated with the strength and weakness of heart function. After mitral valve replacement, BNP showed a trend of increase-decrease and it reached higher value then decreased gradually at postoperative 2 days, which indicates that the cardiac function of patients with RHD after surgery declines in short time period and recovers gradually. Therefore, the dynamic change of BNP concentration can be used as an important reference index for monitoring the condition of RHD patients, evaluation of curative effect and observation of prognosis. Key words: Rheumatic heart disease; Mitral valve replacement; Right ventricular function; Brain natriuretic peptide
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
