Curative effect of Milrinone combined with Esmolol in treatment of severe hand-foot-and-mouth disease

Abstract

Objective To observe the effect of Milrinone combined with Esmolol in the treatment of severe hand-foot-and-mouth disease (HFMD)so as to improve the prognosis. Methods Eighty-two cases of children with critically severe HFMD, who were hospitalized in the Intensive Care Unit of Xuzhou Children's Hospital, were enrolled in the study from may of 2013 to June of 2014, and were randomly divided into a control group and an observation group.The control group was given intravenous Milrinone, and the observation group was given Milrinone combined with Esmolol.The heart rate (HR), systolic blood pressure (SBP), cardiac output(CO), left ventricular ejection fraction (LVEF) and brain natriuretic peptide (BNP), norepinephrine (NE) were detected on admission and checked again 1 hour and 48 hours again after treatment.The changes in the above indicators were compared before and after therapy to evaluate the clinical curative effect. Results (1)There was no significant difference in the HR, SBP, CO, LVEF, BNP and NE between the 2 groups before treatment(all P>0.05). (2)The HR, SBP, CO and LVEF of 2 groups were signi-ficantly improved after 1 hour treatment compared with those before treatment (all P 0.05), but the significant changes were seen in the observation group (all P 0.05). All the observed indicators of the observation group were significantly improved compared with the control group after 48 hours treatment(t=3.76, 2.48, -2.70, -2.27, 5.37, 2.74, all P<0.05). Conclusions Milrinone combined with Esmolol can significantly improve the cardiac function and the vital signs of the children with critically severe HFMD, which can be recommended clinically. Key words: Milrinone; Esmolol; Hand-foot-and-mouth disease