Abstract
Objective To study the clinical treatment effects of large dose of Irbesartan for chronic kidney disease (CKD) patients with their proteinuria.Methods 80 cases as the research object,were given 150 mg/days Irbesartan treatment for 4 weeks.24 patients as control group was given maintenance dose; 56 patients for the observation group gradually increased dose (300 - 600 mg/days),treatment for 12 months,compared to the various index.Results After treatment,the urine protein quantitative and all the indexes had significant changes (P＜O.05); large dose of Irbesartan treatment effective rate was 78.5o-/o (P＞0.05).Conclusions Large dose of Irbesartan in treatment for CKD patients can obviously reduce albuminuria,has very good tolerability and safety. Key words: Irbesartan; Chronic kidney disease(CKD); Proteinuria; Large dose; Curative effect
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