Curative effect of entecavir combined with ganshuang granules on hepatitis B cirrhosis and its influences on liver function

Abstract

Objective To explore the clinical curative effect of entecavir combined with ganshuang granules on hepatitis B cirrhosis. Methods A total of 120 patients with hepatitis B cirrhosis who were admitted to the First People’s Hospital of Jinzhong from January 2017 to December 2018 were enrolled as study objects. They were randomly divided into treatment group (60 cases) and control group (60 cases) based on odd and even numbers. The control group was given routine treatment and entecavir, while treatment group was given ganshuang granule on the basis of control group. Both groups were treated for 6 months. The clinical curative effect, Traditional Chinese Medicine (TCM) symptoms scores, liver function evaluated by total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver fibrosis indexes such as serum hyaluronic acid (HA), type Ⅲ procollagen (PC Ⅲ), type IV collagen (IV-C), liver hardness value and level of serum virus (HBV-DNA) were compared between the two groups. Results The clinical response rate of treatment group was significantly higher than that of control group (96.67% vs. 85.00%, P<0.05). After treatment, TCM syndromes scores, liver function indexes (TBIL, ALT, AST), liver fibrosis indexes (HA, PCIII, IV-C), liver hardness value and HBV-DNA in treatment group were significantly lower than those in control group (P<0.05). Conclusions Ganshuang granule combined with entecavir in treatment of hepatitis B cirrhosis can significantly improve liver function, inhibit fibrosis, reduce serum HBV-DNA level and liver hardness value. Symptoms of patients are significantly improved by the protocol, and curative effect is significant. Key words: Entecavir; Ganshuang granule; Hepatitis B; Liver cirrhosis; Liver function