Curative effect of botulinum toxin A and hyaluronate in the treatment of IC/PBS

Abstract

Objectives To evaluate the efficacy and safety of intravesical botulinum toxin A (BTX–A) injections and instillation of sodium hyaluronate therapy for the treatment of interstitial cystitis/ painful bladder syndrome(IC/PBS). Methods In the 53 patients with IC/PBS, 28 patients received intravesical BTX–A injections and instillation of sodium hyaluronate therapy (group A), and the other 25 patients were given instillation of sodium hyaluronate therapy (group B). Clinical symptoms (micturition frequency per day, maximal micturition volume and odynuria degree score), O'Leary–Sant symptom and problem index were assessed at baseline and then after 2 weeks, 1, 2 and 6 months. Results Before and after therapy, clinical symptoms, O'Leary–Sant symptom and problem index of group A had significant differences (P 0.05). But at various points, clinical symptoms, O'Leary–Sant symptom and problem index of group B had significant differences (P<0.05). After treatment, the result of therapeutic effect evaluation in the two groups had significant differences (P<0.05). There were three patients who got urinary tract infection, and no other side effects. Conclusions Intravesical BTX–A injections and instillation of sodium hyaluronate therapy can rapidly and effectively relieve clinical symptom of IC/PBS. It can better improve lower abdominal pain, excessive urination at night, and urinary frequency, and impove patients' quality of life, and provide a new effctive therapy for IC/PBS. Key words: Cystitis, Interstitial; Botulinum Toxin Type A; Hyaluronic Acid