Curative effect observation of desonide cream in two topical approach for circumscribed neurodermatitis

Abstract

Objective To observe the clinical efficacy of two different ways of desonide cream on circumscribed neurodermatitis.Methods One hundred and twenty circumscribed neurodermatitis patients were divided into two groups randomly.Patients in treatment group were treated with desonide cream coated with the affected area after dressing closed 12 h.Patients in control group were treated with desonide cream to the affected part only.The treatment course in both groups were 2 weeks.The clinical efficacy of two different treatment methods after 2 weeks were compared.Results The cure rate of the treatment group (60.00％) and efficiency (91.67％) were significantly better than those in control group (36.67％ and 76.67％),the differences were significant (P ＜0.05).Two cases in treatment group and one case in control group presented partial heat and redness during the therapy,and the symptoms were disappeared after withdrawal of all treatment.After 8 weeks of treatment,the recurrence rate in treatment group(20.00％) was lower than that in control group (40.00％),the difference between the two groups was significant (P ＜ 0.05).Conclusions The effect of desonide cream coated outside the affected area combine bandaging closed 12 h on circumscribed neurodermatitis is better than that only coated. Key words: Desonide cream; External use; Circumscribed neurodermatitis; Clinical observation