Abstract

Objective To investigate the Jinguishenqi pill combined with acupoint application therapy of kidney yang deficiency type chronic obstructive pulmonary disease(COPD) in the stable period and its influence on immune function. Methods One hundred and eighty patients with stable kidney yang deficiency syndrome (COPD) were divided into observation group and control group, 90 cases in each group.The control group was treated with routine western medicine.The observation group in the control group based on the given Jinguishenqiwan combined with acupoint application therapy.6 minutes walking distance (6MWD) was used to detect exercise tolerance.The modified version of the British medical association respiratory questionnaire (mMRC) was used to detect changes in dyspnea symptoms.The changes of pulmonary function before and after treatment in two groups were detected.The levels of CD3+ , CD4+ and CD4+ /CD8+ were detected before and after treatment in the two groups. Results After treatment, the mMRC index in two groups was significantly decreased, and 6MWD was significantly increased (t=16.284, 9.213, 10.826, 6.058, P<0.05). After treatment, the mMRC index of the observation group was significantly lower than that of the control group, and the 6MWD index was significantly higher than that of the control group.The difference was statistically significant (t=6.112, 2.194, P<0.05). The levels of CD3+ , CD4+ and CD4+ /CD8+ in the observation group were significantly higher than those in the control group (t=9.780, 6.178, 10.544, P<0.05). After treatment, the levels of CD3+ , CD4+ and CD4+ /CD8+ in the observation group were significantly higher than those in the control group.The difference was statistically significant (t=6.352, 5.068, 7.402, P<0.05). The scores of forced expiratory volume in one second (FEV1), forced expiratory volume in one second/forced vital capacity (FEV1/FVC), maximal ventilation per minute (MVV), and FEV1%pred in the two groups after treatment were significantly higher than those before treatment (t=11.177, 24.593, 13.319, 12.483, 6.146, 15.641, 9.494, 5.457, P<0.05). After treatment, the percentage of FEV1, FEV1/FVC, MVV and FEV1%pred in the observation group was significantly higher than that in the control group.The difference was statistically significant (t=4.339, 9.758, 3.906, 6.735, P<0.05). Conclusions The curative effect in the treatment of kidney yang deficiency type COPD in stable period and exactly improve the immune function of Jinguishenqi pill combined with acupoint application. Key words: Jinguishenqi pill; Acupoint application; Kidney yang deficiency; Stable stage of chronic obstructive pulmonary disease; Immune function

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