Curative effect analysis of continuous renal replacement therapy in patients with multiple organ dysfunction syndrome

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Objective To investigate the curative effect of continuous renal replacement therapy(CRRT) in patients with multiple organ dysfunction syndrome(MODS). Methods 194 patients with multiple organ dysfunction syndrome were divided into two groups. 89 patients without using CRRT treatment for various reasons, as a routine treatment group, were treated by the conventional treatment, including etiological treatment, anti-inflammatory, organ function support and other symptomatic supportive treatment.The other 105 patients were treated with continuous renal replacement therapy on the basis of conventional therapy as the CRRT group. analysis of two groups of Patients before and after treatment for 24 hours The acute Physiology and chronic health evaluation Ⅱ score, Marshall score, Sequential Organ Failure Assessment (SOFA) score, the changes of calcitonin original, mean arterial Pressure, creatinine, oxygenation index and 7 days survival rate of two groups of patients before and after treatment for 24 hours were compared, and the efficacy of treatment was analyzed. Results Before and after treatment in the CRRT group, APSCHE Ⅱ scores were (24.1±7.9) and (19.8±7.6), Marshall scores were (7.3±2.7) and (6.8±2.9), and SOFA scores were (11.9±2.7) and (10.8±3.2) with significant differences (P<0.05). Before and after treatment in the conventional group, the APACHE Ⅱ score were (23.2 ± 8.4) and (23.1 ± 8.6), Marshall score were (7.1 ± 3.1) and (7.3 ± 3.1), SOFA score were (11.1±3.3) and (11.2±3.5) with no significant differences. Before and after treatment in the CRRT group, procalcitonin were 10.6 (7.1, 16.1) & 4.7 (2.5, 6.9), mean arterial pressure were (76.3±19.7) and (83.2±15.6), creatinine were 199 (147.5, 328.5) & 149, and oxygenation index were (228.9±105.1) and (269.1±111.5) with significant differences (P<0.05). Before and after treatment in the conventional treatment group, procalcitonin were 13.7 (10.1, 19.6) & 13.4. 10.1, 21.6), mean arterial pressure were (83.0±17.9) and (80.0±15.9), creatinine were 180 (119.5, 281.0) & 195 (113.5, 313.5), and oxygenation index were (286.3±139.3) and(283.2±126.6)with no significant differences. The 7-day survival rate of the CRRT group was significantly improved (P<0.05). Conclusions in Patients with multiple organ dysfunction syndrome were treated early with continuous renal replacement therapy. APACHE Ⅱ grade, Marshall, SOFA score were significantly reduced. Inflammation, cardiovascular system function, renal function, and respiratory function were improved significantly. Sothe short-term survival rate can be significantly improved. Key words: continuous renal replacement therapy; multiple organ dysfunction syndrome; Short-term survival rate