Abstract
Curative and Protective Effect of Salvia Officinalis Oil on Isoprenaline-Induced Congestive Heart Failure in Rats
Highlights
The overall prevalence of congestive heart failure (CHF) is still increasing with a high mortality, because of the ageing of the population and the success in prolonging survival in patients suffering cardiac disease (McMurray et al, 2012)
Effect of isoprenaline on cardiac oxidative stress and antioxidant markers in rats Administration of ISO significantly increased MDA and Nitric oxide (NO), while decreased the total antioxidant capacity (TAC) as compared to the control group. prophylactic and treatment effects of sage oil on cardiac oxidative stress and antioxidant markers in isoprenaline-induced CHF in rats are illustrated in Figures 5, 6, respectively
Prophylactic administration of either sage oil at both tested dosage levels or digoxin significantly decreased this elevation as compared to CHF group but didn’t normalize it (Figure 7a)
Summary
The overall prevalence of congestive heart failure (CHF) is still increasing with a high mortality, because of the ageing of the population and the success in prolonging survival in patients suffering cardiac disease (McMurray et al, 2012). Isoprenaline (ISO) is a nonselective β1- and β2- adrenergic receptor agonist and large doses can induce heart failure by several mechanisms, including an increase in intracellular cyclic adenosine monophosphate (cAMP), calcium overload, ischemia, and oxidative stress (Remião et al, 2001; Ellison et al, 2007). Salvia officinalis L. have been used as traditional herbal medicine and its essential oils have been used in the treatment of large range of diseases like, nervous system, heart and blood circulation, respiratory, digestive, metabolic and endocrine diseases (Bouajaj et al, 2013; Hamidpour et al, 2014). As essential oils are very important sources for the screening of anticancer, antimicrobial, antioxidant, and free radical scavenging agents (Hussain et al, 2011).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
