Cupper-catalyzed an efficient synthesis, characterization of 2-substituted benzoxazoles, 2-substituted benzothiazoles derivatives and their anti-fungal activity

Abstract

Abstract An efficient synthesis of 2-substituted benzoxazoles, and 2-substituted benzothiazole from condensation of 2-aminophenol, and 2-aminothiophenol react with various aldehydes in Cu2O in the presence of DMSO oxidant system has been developed. This reaction is operationally simple, proceeds with copper catalysts, tolerates a wide range of functionalities, and provides elemental analysis (C, H, N) desired products in good to excellent yields. All the synthesized compounds are screening their anti-fungal activity. Among all the compounds shows good activity 3j, 3q, 3aa, 3ac, 3ad, 5c and 5e compounds shows equal to reference drug.