Cu–Ni bimetallic reusable catalyst for synthesis of propargylamines via multicomponent coupling reaction under solvent-free conditions

Abstract

A Cu–Ni bimetallic catalyst has been used as a reusable catalytic system for the multicomponent coupling reaction of aldehydes, phenylacetylene and secondary amines for the synthesis of propargylamines under solvent-free conditions. The reaction did not require any other additives such as an inorganic base. The bimetallic catalyst displayed high activity and gives propargylamines in good to excellent yields. This method provides a wide range of substrate applicability. The catalyst could be magnetically separated and reused without loss in activity.