Abstract
There were few studies of cumulative live birth rates (CLBRs) based on multicenter reproductive clinical data from the general Chinese population. Here we report a retrospective cohort study, including 14 311 women with 17 315 cycles, in three reproductive centers to evaluate two estimated parameters of CLBRs with multiple transfer cycles of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a Chinese population. We found that CLBRs were related to female age and endometrial thickness. By the fourth transfer cycle, the conservative and optimal estimates of CLBRs were 52.95% and 77.30% in women under 30 years of age, and 18.17% and 26.51% in those 37 years of age or older, respectively. The two estimates were 44.70% and 63.15% in women with endometrial thickness more than 7 mm, and 32.05% and 46.18% in those with less than 7 mm, respectively. In addition, body mass index (BMI), duration of infertility, and infertility diagnoses may also be related to CLBRs on certain conditions. The findings from this study on CLBRs after multiple transfer cycles of IVF/ICSI treatment on different conditions in the Chinese population should be beneficial to both infertile couples and clinicians.
Highlights
Assisted reproductive technology (ART) has evolved rapidly since its invention 40 years ago[1], and up to now, more than 6 million people were estimated to have been born all over the world[2]
We considered the following characteristics for women at the start of their first treatment: female age, duration of infertility (
Live birth rate (%) Live birth rate (%). This is one the of the largest reports of cumulative live birth rates (CLBRs) based on ART treatment cycles derived from multiple clinic data in China
Summary
Assisted reproductive technology (ART) has evolved rapidly since its invention 40 years ago[1], and up to now, more than 6 million people were estimated to have been born all over the world[2]. With the development of embryo cryotherapy technology, thawed frozen embryo transfers (FETs) have been widely applied[8,9] and more times of embryo transplantation can be performed within a single ovarian stimulation and oocyte retrieval process. Researchers found cumulative live birth rates (CLBRs) based on complete treatment cycles might be more suitable to evaluate the efficacy of fresh stimulated cycle and all subsequent thawed cycles[10,11]. In China, one of the largest studies about CLBRs was conducted at the Peking University Third Hospital, in which the conservative and optimal estimates after eight cycles can reach up to 69.1% and 90.3%, respectively[14]. The reported influencing factors of CLBRs such as female age, weight decrease, low-calorie diet, and physical exercise need validation in different populations[16,17]
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