Abstract
Multiple independent cancer susceptibility loci at chromosome 8q24 have been identified by GWAS (Genome-wide association studies). Forty six articles including 60,293 cases and 62,971 controls were collected to conduct a meta-analysis to evaluate the associations between 21 variants in 8q24 and prostate cancer risk. Of the 21 variants located in 8q2\\5 were significantly associated with the risk of prostate cancer. In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer. Our study showed that variants in the 8q24 region are associated with prostate cancer risk in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of prostate cancer.
Highlights
Prostate cancer (PCa) is the commonest non-cutaneous malignancy in men all over the world
All studies included in this meta-analysis must meet all the following inclusion criteria: (i) evaluating the associations of the 8q24 variants with prostate cancer risk; (ii) providing sufficient data or multivariate-adjusted risk estimates [e.g., odds ratios (ORs), hazard ratios (HRs), relative risks (RRs), 95% confidence intervals (CIs) or standard errors (SEs)] to calculate these estimates
The full text of these 85 articles was reviewed in detail, and 46 studies were eligible in this meta-analysis
Summary
Prostate cancer (PCa) is the commonest non-cutaneous malignancy in men all over the world. It was proved that 8q24 region was associated with lots of cancers, including breast (Pereira et al, 2016), prostate (Hubbard et al, 2016), bladder (Kiltie, 2010), colon (Ling et al, 2013), lung (Zhang et al, 2012), gliomas (Rice et al, 2013), and so on These susceptibility loci do not affect coding DNA, interestingly, these loci showed strong linkage disequilibrium (LD) as they often tightly linked with many SNPs. further study found that there are many enhancers in 8q24 region, and the rs6983267-containing enhancer interacts with the MYC gene by binding with TCF7L2 (TCF4), and alter the sensitivity to WNT signaling (Tuupanen et al, 2009). Based on the above compelling evidence, it was supposed that the 8q24 variants played important roles in prostate carcinogenesis
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