Abstract
It is well-known that oxidative stress plays critical roles in the pathogenesis of atherosclerotic diseases. In this study, we examined the association between four common genetic variants related to oxidative stress (glutamate-cysteine ligase modifier subunit (GCLM) C-588T, myeloperoxidase G-463A, human paraoxonase-1 Gln192Arg, and NADPH oxidase p22phox C242T) and the prevalence of myocardial infarction in type 2 diabetic patients. All type 2 diabetic patients who periodically attended the outpatient diabetes clinics of five participating hospitals were asked to participate in this study. Subjects who were eligible had type 2 diabetes, diagnosed by diabetologists based on World Health Organization criteria, and were aged ≥50 years. A total of 2,561 type 2 diabetic subjects were included: men, 62%; age, mean ± SD 60.9 …
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