Cumulative Doses to Brain and Other Critical Structures After Multisession Gamma Knife Stereotactic Radiosurgery for Treatment of Multiple Metastatic Tumors.

Jianling Yuan,Yoichi Watanabe,Paul Wayne Sperduto,Kathryn Ellen Dusenbery,Chung K Lee,Richard Lee,Damien C Mathew

doi:10.3389/fonc.2018.00065

Jianling Yuan, Yoichi Watanabe + Show 5 more

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https://doi.org/10.3389/fonc.2018.00065

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Abstract

Repeat stereotactic radiosurgery (SRS) is an attractive alternative to whole brain radiation therapy (WBRT) for treatment of recurrent brain metastases (BM). The purpose of this study is to determine the cumulative doses to the brain and critical normal structures in patients who underwent repeat courses of Gamma Knife (GK) SRS. We retrospectively identified ten patients who received at least three GK-SRS sessions for multiply recurrent BM at our institution from 2013 to 2016. We used Velocity™ 3.1.0 software to co-register the magnetic resonance imaging images and the dose data of all treatment sessions for each patient. The cumulative doses to brain, lenses, eyes, brainstem, optic nerves, chiasm, and hippocampi were calculated. Dose-volume histograms, as well as the mean, median and maximum doses of these structures, were analyzed. The median number of SRS was five sessions (range = 3-7 sessions) per patient over a median treatment span of 510 days (112-1,197 days), whereas the median number of metastatic tumors treated per patient was 25.0 (10-63). The median of the total tumor volume was 9.5 cc (2.3-75.9 cc). The median of the mean cumulative dose to the whole brain was 4.1 Gy (1.7-16.4 Gy). The medians of the maximum doses to the critical structures were as follows: brainstem, 6.1 Gy (2.2-28.9 Gy), chiasm, 3.9 Gy (1.8-10.8 Gy), right optic nerve, 2.9 Gy (1.2-9.0 Gy), and left optic nerve, 2.6 Gy (1.0-6.5 Gy). The medians of the mean and maximum cumulative doses to the hippocampi were 3.4 Gy (1.0-14.4 Gy) and 13.8 Gy (1.5-39.3 Gy), respectively. The median survival for the entire cohort was 26.7 months, and no patients developed radiation necrosis. Our study demonstrated that multisession GKSRS could be delivered with low cumulative doses to critical normal structures. Further studies are required to fully establish its role as an alternative treatment strategy to WBRT for the treatment of multiply recurrent BM.

Highlights

Brain metastases (BM) are the most common type of intracranial tumors
From a prospectively maintained database of patients treated with GKSRS at our institution, we identified all patients who Abbreviations: SRS, stereotactic radiosurgery; GK, gamma knife; RTOG, radiation therapy oncology group; WBRT, whole brain radiation therapy; BM, brain metastasis
We identified a total of 10 patients who underwent three or more GKSRS sessions to treat ≥10 lesions at our institution from 2013 to 2016 (Table 1)

Summary

Introduction

Brain metastases (BM) are the most common type of intracranial tumors. Older population-based studies in the 1970s and 1980s have shown an incidence rate of up to 10% among patients diagnosed with cancer [1]. Whole brain radiation therapy (WBRT) is the standard treatment option for BM, either alone or in combination with stereotactic radiosurgery (SRS). This is driven by the rationale that the entire brain may be “seeded” with micrometastatic disease since the most common route of dissemination is hematogenous [7]. WBRT is well documented to have a negative impact on neurocognitive function, cerebellar function, and quality of life (QOL) [2, 3, 14] This issue is becoming increasingly relevant in the era of targeted therapy and immunotherapy, which has significantly prolonged survival in select patients

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