CUMULATIVE CLINICAL PREGNANCY RATES PER OOCYTE RETRIEVAL AFTER IN VITRO FERTILIZATION

Abstract

To investigate cumulative clinical pregnancy rates (CCPR) and to improve patient counseling with the prognostic pregnancy outcome per oocyte retrieval cycle. DESIGN: Retrospective study. All classical IVF or ICSI Cycles involving fresh embryo transfer carried out between January 2015 and December 2018 at our clinic were investigated, including fresh ET only and fresh ET followed by 1-6 time frozen-thawed embryo transfers (FET). Both fresh ET and FET were included to calculate the CCPR. Clinical pregnancy was confirmed by the observation of a gestational sac with a fetal heartbeat on ultrasound evaluation. Results were analyzed by using chi-square test (P=0.05). This study included 535 fresh ET cycles and 330 FET cycles. The average age of the patients was 35.9 (26-45). The ratio of fresh cycles with frozen embryos after transfer was 75% (402/535). The average number of embryos cryopreserved per cycle was 3.1. The average number of embryos transferred was 1.3. The CCPR per oocyte retrieval increased by each cycle of frozen-thawed embryo transfer (Table 1). The significant differences in CCPR were found among Fresh, FET1 and FET2 cycles. No significant differences in CCPR were observed among FET2, FET3, FET4, FET5 and FET6 cycles.Tabled 1Table 1. The cumulative clinical pregnancy rates per oocyte retrievalCycleClinical pregnancy rateCumulative clinical pregnancy rateFresh42.4% (227/535)42.4% (227/535) aFET146.8% (88/188)58.9% (315/535) bFET243.1% (34/80)65.2% (349/535) cFET342.9% (15/36)68.0% (364/535) cFET46.3% (1/16)68.2% (365/535) cFET537.5% (3/8)68.8% (368/535) cFET650.0% (1//2)69.0% (369/535) ca,b,c Values with different superscript letters within the same column are significant different (p<0.05) Open table in a new tab a,b,c Values with different superscript letters within the same column are significant different (p<0.05) Our data analysis indicated that the CCPR per oocyte retrieval increased until the second FET cycle with no benefit for additional FET cycles to have one pregnancy. The results provided here may be useful in counseling patients on the high pregnancy outcome (69.0%) per oocyte retrieval cycle.