Abstract
There continue to be conflicting data regarding the outcomes of people with HIV (PWH) who have COVID-19 infection with most studies describing the early epidemic. We present a single site experience spanning a later timeframe from the first report on January 21, 2020 to January 20, 2021 and describe clinical outcomes and predictors of hospitalization among a cohort of PWH in an urban center in Connecticut, USA. Among 103 PWH with controlled HIV disease, hospitalization occurred in 33% and overall mortality was 1%. HIV associated factors (CD4 count, HIV viral suppression) were not associated with hospitalization. Chronic lung disease (OR: 3.35, 95% CI:1.28-8.72), and cardiovascular disease (OR: 3.4, 95% CI:1.27-9.12) were independently associated with hospitalization. An increasing number of non-communicable comorbidities increased the likelihood of hospitalization (OR: 1.61, 95% CI:1.22-2.13).
Highlights
The first laboratory-confirmed case of coronavirus disease (COVID-19) secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United States (US) was reported on January 21, 2020 [1]
Median age (IQR) Age 50 yrs, n (%) Age>65 yrs, n (%) Women, n (%) African Americans, n (%) Latinx, n (%) Median years living with HIV (IQR) History of AIDS, n (%) History of CD4
While other studies have demonstrated that diabetes and chronic kidney disease were significantly associated with severe disease and/or poor outcomes, we found that active substance use and Hepatitis C, were significantly correlated on bivariate but not on adjusted analysis, possibly attributable to sample size [4]
Summary
The first laboratory-confirmed case of coronavirus disease (COVID-19) secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United States (US) was reported on January 21, 2020 [1]. Initial reports from China identified a number of risk factors for severe COVID-19 and mortality, including older age, male gender, immunosuppressed status, and co-morbidities such as hypertension, diabetes, chronic cardiovascular and respiratory disease [3,4,5,6]. The earliest case series showed that clinical outcomes among PWH were not any worse than those for patients without HIV [3, 7, 8] and found no excess risk of morbidity and mortality in symptomatic SARS-CoV-2 co-infected patients with fully.
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