Abstract
Culture of human leukaemic blood cells in vitro; some effects of X-rays.
Highlights
With a dose of 1000 r the ratio, at 8 hours, of immature cells in irradiated to those in control cultures varied from 76 to 111 per cent
In spite of the non-homogeneity of the material, the results show clearly the following points: Irradiation of cultures of leucocytes from chronic myeloid leukaemias with 100 r produced a significant reduction in the number of dividing cells for at least 8 hours
The main purpose of the work reported in this paper was to determine whether doses of X-rays within the range of those used therapeutically could produce changes in cultures of human leukaemic leucocytes; whether such changes, if present, could be analysed quantitatively; and if that were so, whether any EXPLANATION OF PLATE
Summary
With a dose of 1000 r the ratio, at 8 hours, of immature cells in irradiated to those in control cultures varied from 76 to 111 per cent. There was a highly significant reduction in the number of immature cells in cultures 24 and 48 hours after irradiation with 1000 r.
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