Abstract

BackgroundType 2 diabetes mellitus (T2DM) is now one of the leading causes of disease-related deaths globally. India has the world’s second largest number of individuals living with diabetes. Lifestyle change has been proven to be an effective means by which to reduce risk of T2DM and a number of “real world” diabetes prevention trials have been undertaken in high income countries. However, systematic efforts to adapt such interventions for T2DM prevention in low- and middle-income countries have been very limited to date. This research-to-action gap is now widely recognised as a major challenge to the prevention and control of diabetes. Reducing the gap is associated with reductions in morbidity and mortality and reduced health care costs. The aim of this article is to describe the adaptation, development and refinement of diabetes prevention programs from the USA, Finland and Australia to the State of Kerala, India.MethodsThe Kerala Diabetes Prevention Program (K-DPP) was adapted to Kerala, India from evidence-based lifestyle interventions implemented in high income countries, namely, Finland, United States and Australia. The adaptation process was undertaken in five phases: 1) needs assessment; 2) formulation of program objectives; 3) program adaptation and development; 4) piloting of the program and its delivery; and 5) program refinement and active implementation.ResultsThe resulting program, K-DPP, includes four key components: 1) a group-based peer support program for participants; 2) a peer-leader training and support program for lay people to lead the groups; 3) resource materials; and 4) strategies to stimulate broader community engagement. The systematic approach to adaptation was underpinned by evidence-based behavior change techniques.ConclusionK-DPP is the first well evaluated community-based, peer-led diabetes prevention program in India. Future refinement and utilization of this approach will promote translation of K-DPP to other contexts and population groups within India as well as other low- and middle-income countries. This same approach could also be applied more broadly to enable the translation of effective non-communicable disease prevention programs developed in high-income settings to create context-specific evidence in rapidly developing low- and middle-income countries.Trial registrationAustralia and New Zealand Clinical Trials Registry: ACTRN12611000262909. Registered 10 March 2011.

Highlights

  • Type 2 diabetes mellitus (T2DM) is one of the leading causes of disease-related deaths globally

  • Oldenburg and their colleagues used the Fin-DPS as a benchmark for the Good Ageing in Lahti (GOAL) Region Lifestyle Implementation Trial in Finland [13, 14], and the Greater Green Triangle Diabetes Prevention Program (GTT United States Diabetes Prevention Program (DPP)) adapted and tested the GOAL model in Australia [15]

  • Due to the lack of evidence-based diabetes prevention programs in India and other Low- and middle income country (LMIC) [38], the Kerala Diabetes Prevention Program (K-DPP) program was adapted to Kerala, India from the GOAL Lifestyle Implementation Trial in Finland [13, 14], the United States Diabetes Prevention Program (US DPP) [9, 45] and the GGT DPP in Australia [15]

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Summary

Introduction

Type 2 diabetes mellitus (T2DM) is one of the leading causes of disease-related deaths globally. Oldenburg and their colleagues used the Fin-DPS as a benchmark for the Good Ageing in Lahti (GOAL) Region Lifestyle Implementation Trial in Finland [13, 14], and the Greater Green Triangle Diabetes Prevention Program (GTT DPP) adapted and tested the GOAL model in Australia [15] These studies have been followed by a number of translational studies based on either the Fin-DPS or the US DPP model in other high-income countries (HICs) such as the United States [16,17,18], United Kingdom [19, 20], Netherlands [21], Europe [22,23,24], Australia [25] and Japan [10, 26]. Such protocols are paving the way forward for future adaption of diabetes prevention programs, whilst ensuring fidelity of the original evidence-based intervention is maintained

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