Abstract
In this paper, near-infrared (NIR) fluorescent CuInS2 QDs@SiO2 nanobeads were prepared and used as fluorescent nanoprobes for prostate cancer cells imaging. The core–shell CuInS2 QDs@SiO2 nanobeads with controllable particle sizes were synthesized via a reverse microemulsion method. Further surface modifications were performed for grafting amino groups on the surface of the NIR CuInS2 QDs@SiO2 nanobeads. For prostate cancer cell imaging, anti-PSCA antibody was conjugated to the NIR CuInS2 QDs@SiO2 nanobeads to prepare the anti-PSCA–QDs@SiO2 nanoprobe. The specific binding of the antibody conjugated CuInS2 QDs@SiO2 nanobeads to the surface of human prostate cancer cells (PC-3M) was confirmed by fluorescence microscopy. MTT assay and fluorescence microscopy images showed that the anti-PSCA-conjugated NIR CuInS2 QDs@SiO2 nanoprobe was a non-toxic nanoprobe and had high-specificity in cell imaging. The CuInS2 QDs@SiO2 nanoprobe as an efficient NIR imaging nanoprobe could be used for target imaging, biological assays and early diagnosis of cancer.
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