CuI@Al2O3 catalyzed synthesis of 2-aminonicotinonitrile derivatives under solvent free condition

Abstract

A Green approach for the synthesis of 2-aminonicotinonitriles from oxime acetate as enamine precursor, aldehyde and malononitrile under neat condition without the use of additive in presence of CuI@Al2O3 nanocatalyst is reported. Wide substrate scope, high yield in shorter reaction time, avoid the usage of bases/additives with better green chemistry matrices like low E factor and PMI, high values of atom economy, carbon efficiency and reaction mass efficiency as compared with literature methods. CuI@Al2O3 nanocatalyst was recovered and recycled five times without significant decrease in its catalytical activity.