Cuffless Blood Pressure Estimation Using Dual Physiological Signal and Its Morphological Features

Abstract

Prehypertension is difficult to diagnose early because of its hidden nature. Long-term monitoring of blood pressure (BP) can help in the early detection and timely treatment of this condition. This study proposes an innovative and efficient BP detection platform that combines portable electrocardiography (ECG) and photoplethysmogram (PPG) signals simultaneous acquisition equipment and BP detection algorithm to obtain real-time BP values conveniently and accurately for a long time. In this study, nine kinds of feature parameters and classification algorithm are used to build multiple linear regression (MLR) models. It not only adopts the Multi-Parameter Intelligent Monitoring in Intensive Care Units (MIMIC-II) database to train and validate the model but also uses self-developed equipment for acquisition and verification in long-term health monitoring. According to the experimental results, the mean absolute error (MAE) and standard deviation (SD) of systolic BP (SBP) have estimated values of 4.46 and 3.20 mmHg, respectively, and simultaneously, the MAE and SD of diastolic BP (DBP) are 4.20 and 3.28 mmHg, respectively. Moreover, both SBP and DBP experimental results conform to the Advancement of Medical Instrumentation BP standard. The proposed BP acquisition platform is proven to be capable of easily acquiring ECG and PPG signals with the proposed sensor device, and the MLR algorithm can also effectively and accurately monitor BP values for a long time.