Cucurbit[8]uril as Building Block for Facile Fabrication of Well‐Defined Organic Crystalline Nano‐objects with Multiple Morphologies and Compositions

Abstract

Cucurbit[n]urils (CB[n]) have great potential in material and medical applications due to their advantageous molecular recognition properties. Despite organic microcrystals being highly desirable in materials science and the medical industry, CB[n]-based micro- and nanocrystals have not been reported. A facile and efficient approach for producing CB[8]-based organic crystals with well-defined micro- and nanostructures is described, based on the unique host-guest chemistry of CB[8] macrocycle with small guest molecules. The described strategy allows fabrication of micro- and nanocrystals with multiple morphologies and compositions by simply adjusting the preparation conditions and the type of guest molecules. The mechanisms for the formation of the micro/nanocrystals are studied, and morphology-dependent optical and thermal properties typical of organic micro/nanocrystals are described. Additionally, attractive potentials of the prepared microcrystals are shown upon storing small molecules, and in optical applications. The molecular recognition abilities of CB[8] are highlighted in both its preparation process and potential application.