Abstract
AbstractThe design of nanocarriers that selectively target the liver or kidney is a significant challenge in drug delivery due to the diverse physiological structures and inherent characteristics, as well as their distinct requirements for nanocarriers. Herein, a strategy to synthesize a series of second near‐infrared region (NIR‐II) emitting gold nanocarriers for fine‐tuning liver or kidney‐specific delivery via altering their surface chemistry using cucurbit[7]uril (CB[7]) and Cys‐Arg‐Gly‐Asp (CRGD) peptide is reported. Accordingly, it shows that ultrasmall nanocarriers can facilitate kidney‐targeted delivery in cisplatin‐induced acute kidney injury (AKI) mice, which significantly boosted the accumulation of dexamethasone (DXM) loaded onto the nanocarriers at the site of injured kidneys, thereby achieving improved therapeutic results. Thus, this organ‐specific delivery strategy holds tremendous promise for improving drug delivery efficiency and providing new perspectives and methods for personalized treatments.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
