Abstract
• Cu-catalyzed direct C1−H difluoromethylation of pyrrolo[1,2-a]quinoxalines with BrCF 2 CO 2 Et or BrCF 2 CONEt 2 is described. • A series of difluoromethylated pyrrolo[1,2-a]quinoxalines were obtained with good yields. • The method is characterized by good functional group tolerance, broad substrate scope as well as gram-scale synthesis. An efficient Cu-catalyzed direct C1−H difluoromethylation of pyrrolo[1,2- a ]quinoxalines with BrCF 2 CO 2 Et or BrCF 2 CONEt 2 has been reported, providing to a series of difluoromethylated pyrrolo[1,2- a ]quinoxalines with generally good yields. This approach features good compatibility with substituents, broad substrate scope, and gram-scale synthesis. The further transformations of the products are also examined.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.